%0 Journal Article
%T HLA-A, B, and DRB1 gene polymorphisms in Mongol ethnic group of Inner Mongolia, China<br>内蒙古地区蒙古族HLA-A、B、DRB1基因座多态性分析
%A SHEN Chun-Mei
%A ZHU Bo-Feng
%A LI Sheng-Bin
%A <br>沈春梅
%A 朱波峰
%A 李生斌
%J 遗传
%D 2008
%I 
%X We investigated the genetic polymorphisms of HLA-A, B, DRB1 alleles and haplotype frequencies in Mongols from Inner Mongolia, China. A PCR-based reverse line-strip sequence specific oligonucleotide hybridization method was used to determine the alleles of HLA-A, B, DRB1 in 106 unrelated, healthy Mongol individuals of Inner Mongolia. Allelic and haplotype frequencies of these loci were calculated by the maximum likelihood estimator method. Altogether, 13 HLA-A alleles, 29 HLA-B alleles and 13 HLA-DRB1 alleles were observed in the population. The most frequent HLA A-B, B-DRB1, and A-B-DRB1 haplotypes were HLA-A*02-B*46 (0.0510), HLA-A*02-B*13 (0.0495), HLA-A*02-B*51 (0.0442); HLA-B*13-DRB1*07(0.0555), HLA B*46-DRB1*09 (0.0378), HLA-B*35-DRB1*13(0.033); and HLA-A*02-B*13- DRB1*07(0.033019), HLA-A*02-B*46-DRB1*09 (0.031985), respectively. These results indicated that the HLA loci are highly polymorphic in Mongols of Inner Mongolia, and haplotypes HLA-A*24-B*14, HLA-A*32-B*63 have significant linkage disequilibrium.
%K 内蒙古地区蒙古族
%K 人类白细胞抗原
%K 单倍型频率
%K 遗传多态性
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=2FCA84C842BF680CF29FB49A75BA63AF&yid=67289AFF6305E306&vid=340AC2BF8E7AB4FD&iid=0B39A22176CE99FB&sid=F260CE035846B3B8&eid=BBF7D98F9BEDEC74&journal_id=0253-9772&journal_name=遗传&referenced_num=1&reference_num=14