%0 Journal Article
%T Genetic polymorphism of 15 STR loci in Tibetan population<br>西藏藏族人群15个短串联重复序列基因座的遗传多态性
%A LI Ning
%A SU Yu-Hong
%A XI Huan-Jiu
%A REN Fu
%A HUANG Ke-Qiang
%A XIAO Yan-Jie
%A WEN You-Feng
%A LI Chun-Shan
%A LI Chang-Yong
%A WANG Kun
%A CHENG Jian-Guo
%A <br>李宁
%A 苏玉虹
%A 席焕久
%A 任甫
%A 黄克强
%A 肖艳杰
%A 温有峰
%A 李春山
%A 李长勇
%A 王鲲
%A 成建国
%J 遗传
%D 2008
%I 
%X The polymorphism distributions of 15 STR loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, VWA, TPOX, D18S51, D5S818, and FGA) were investigated in a Tibetan population by multiplex PCR amplification using five fluorochromes (6FAM, VIC, NED, PET, LIZ). Gene frequency, discrimination power (DP), heterozygosity (H), polymorphism information content (PIC) and probability of paternity exclusion (EPP) were calculated, and all loci were tested for Hardy-Weinberg equilibrium. Results indicate that the gene frequency of these 15 STR loci is in Hardy-Weinberg equilibrium. The DP is at 0.7555-0.9602, H is at 0.5651-0.8530, PIC is at 0.5528-0.8456, and EPP is at 0.3811-0.8549. Cumulative DP of the 15 STR is 0.99999999, and cumulative EPP is 0.999999997. Therefore, these 15 STR loci can be used as genetic markers of Tibetan populations in anthropological studies, linkage analysis of genetic diseases, individual identification and paternity testing in forensic medicine.
%K 短串联重复序列
%K 多态性
%K 藏族
%K 聚合酶链式反应
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=FF8823AEEC2A86D7808EA1DC71AC5C94&yid=67289AFF6305E306&vid=340AC2BF8E7AB4FD&iid=DF92D298D3FF1E6E&sid=0075485171F295AA&eid=353B961D86F026C0&journal_id=0253-9772&journal_name=遗传&referenced_num=0&reference_num=13