%0 Journal Article
%T The genetic polymorphism of cytokine genes in Zhejiang Han indi-viduals<br>浙江汉族人群细胞因子基因多态性分析
%A ZHANG Wei
%A ZHU Hong
%A LV Qin-Feng
%A WANG Wei
%A HAN Zhe-Dong
%A ZHU Fa-Ming
%A YAN Li-Xing
%A <br>章伟
%A 祝宏
%A 吕沁风
%A 王炜
%A 韩浙东
%A 朱发明
%A 严力行
%J 遗传
%D 2007
%I 
%X In order to investigate the genetic polymorphism of 13 cytokines genes in Han individuals from Zhejiang. The polymerase chain reaction-sequence specific primers (PCR-SSP) method was used to determine genetic polymorphisms in 100 unrelated healthy Han individuals from Zhejiang province. We found that: (1) The frequency of the TGFbeta (G codon 25) allele is 1.00 and no TGFbeta (C codon 25) allele is found. (2) The frequencies of IL-1alpha(C-889), IL-1beta(C +3962), IL-4 (T-1098), IL-6 (G-174), IL-6 (G nt565), IL-10 (A-1082) and TNFalpha (G-238) alleles are more than 0.95; while the frequencies of IL-1alpha (T-889), IL-1alpha (T +3962), IL-4 (G-1098), IL-6 (A-174), IL-6 (A nt565), IL-10 (G-1082), TNFalpha (A-238) alleles are less than 0.05. (3) The haplotype frequency of the high-producer-type GCC in IL-10 gene is 0.05, while the low-producer-type ATA is 0.735. The haplotype frequency of the high-producer-type TG in the TGFbeta gene is 0.49, while the low-producer-type CC is 0. The haplotype frequency of the high-producer-types AG and AA in the TNFalpha gene is 0.055, while of the low-producer-types GG and GA is 0.945. The results showed that the genetic polymorphism of cytokine genes in Han individuals from Zhejiang Province is distinctive.
%K cytokine
%K genotype
%K haplotype
%K Han individuals<br>细胞因子
%K 基因型
%K 单倍型
%K 汉族人群
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=5B35FD5BC49C6315&yid=A732AF04DDA03BB3&vid=771469D9D58C34FF&iid=0B39A22176CE99FB&sid=D46BA3D3D4B3C585&eid=3A0155B37D8FF829&journal_id=0253-9772&journal_name=遗传&referenced_num=0&reference_num=7