%0 Journal Article
%T Mapping of pathogenic genes in two families with auto-somal dominant ichthyosis vulgaris<br>两个常染色体显性遗传寻常性鱼鳞病家系致病基因的定位
%A GONG Hui-Yong
%A ZHANG Jing
%A HU Zheng-Mao
%A WU Ling-Qian
%A LIANG De-Sheng
%A XIE Zhi-Guo
%A PAN Qian
%A BU Feng-Xiao
%A PENG Yu
%A XIA Kun
%A XIA Jia-Hui
%A <br>龚惠勇
%A 张静
%A 胡正茂
%A 邬玲仟
%A 梁德生
%A 谢志国
%A 潘乾
%A 卜枫啸
%A 彭聿
%A 夏昆
%A 夏家辉
%J 遗传
%D 2008
%I 
%X To localize the pathogenic genes of autosomal dominant ichthyosis vulgaris, we ascertained two ichthyosis vulgaris families from Hunan Province. Venous blood samples were collected from affected and unaffected family members and genomic DNA was extracted. We then performed genome scan and linkage analysis using microsatellite markers around known ichthyosis vulgaris loci in chromosomes 1 and 10. In family 1, the locus linked to ichthyosis vulgaris was located near D1S498 (1q21), which overlapped with known ichthyosis vulgaris loci. In family 2, however, all known loci for ichthyosis vulgaris were excluded and the new locus remains to be identified.
%K 寻常性鱼鳞病
%K 微卫星标记
%K 连锁分析
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=F4DCCD9D328149F5F5788A9BF01EF58E&yid=67289AFF6305E306&vid=340AC2BF8E7AB4FD&iid=DF92D298D3FF1E6E&sid=85C7135C065B9251&eid=138D3449C4A7D4E9&journal_id=0253-9772&journal_name=遗传&referenced_num=1&reference_num=16