%0 Journal Article
%T Studies on Reversion of a Transformant Line and Loss of Exogenous ras Oncogene after Treatment with an Inhibitor of PARP Enzyme<br>PARP酶抑制剂诱导转化细胞逆转及外源ras癌基因丢失的研究 Studies on Reversion of a Transformant Line and Loss of Exogenous Ras Oncogene after Treatment with an Inhibitor of PARP Enzyme
%A Yang Qiwei
%A Dong Yuanshu
%A Chen Yawen
%A Chen Defeng
%A <br>杨其伟
%A 董元舒
%A 陈雅文
%A 陈德风YANG Qi-Wei
%A DONG Yuan-Shu
%A CHEN Ya-Wen
%A CHEN De-Feng
%J 遗传
%D 1996
%I 
%X A transformant line obtained by transfection of NIH3T3 cells with c-Ha-T24-ras gene was treated with 5mmol / L benzamide, an inhibitor of PARP cnzyme for 4 weeks. Some changes in cellular properties of the transformant line werc obscrved. Concomitant with these changes was the deletion of the exogenous c-Ha-T24-ras which had been integrated into genomic DNA of recipient cells.
%K Poly (ADP-ribosyl) ation
%K Transformed cell reversion
%K ras oncogene
%K Deletion<br>转化细胞逆转
%K ras癌基因
%K 基因丢失
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=2F3F9D1C0B064B8DCF1C87AF64F28D13&yid=8A15F8B0AA0E5323&vid=13553B2D12F347E8&iid=38B194292C032A66&sid=B31275AF3241DB2D&eid=5D311CA918CA9A03&journal_id=0253-9772&journal_name=遗传&referenced_num=6&reference_num=3