%0 Journal Article %T Analysis of Polymorphisms on Lewis Blood Group Antigen Related SE Gene in the Populations in Shandong with High-risk of Gastric Cancer and Beijing
山东临朐胃癌高发人群和北京人群Lewis血型抗原相关SE基因多态性分析 Analysis of Polymorphisms on Lewis Blood Group Antigen Related SE Gene in the Populations in Shandong with High-risk of Gastric Cancer and Beijing %A Jin-Mai Jiang %A Kai-Feng Pan %A Jun-Ling Ma %A Tao Ning %A Gui-Rong Lu %A Wei-Cheng You %A Yang Ke %A
姜劲迈 %A 潘凯枫 %A 马峻岭 %A 宁涛 %A 路桂荣 %A 游伟程 %A 柯杨JIANG Jin-Mai %A PAN Kai-Feng %A MA Jun-Ling %A NING Tao %A LU Gui-Rong %A YOU Wei-Cheng %A KE Yang %J 遗传 %D 2003 %I %X To study the relation between host genetic background and the susceptibility to H.pylori associated gastric cancer, PCR-sequencing and PCR-RFLP were used to screen SECRETOR gene polymorphisms in 142 subjects including 69 cancer patients and 73 non-cancer individuals from high-risk area of gastric cancer in Shandong and 93 control individuals from Beijing.Results showed that the difference in se(w)/se(w) distribution between non-cancer individuals and Beijing population was significant (P<0.01,OR is 3.06,95% CI,1.28-7.30), but that between cancer patients and non-cancer individuals was not with significance. SE gene polymorphism was not relevant to H.pylori infection. We concluded that Shandong population from high-risk area of gastric cancer shared a high distribution of se(w)/se(w) genotype,which could be considered as one of the genetic markers. %K gastric cancer %K Lewis blood group antigen %K SECRETOR gene %K gene polymorphism
山东临朐 %K 胃癌 %K 高发人群 %K 北京人群 %K Lewis血型抗原 %K SECRETOR基因 %K 基因多态性 %K 幽门螺杆菌 %K 遗传标记 %U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=27A138A1C8972594&yid=D43C4A19B2EE3C0A&vid=C5154311167311FE&iid=38B194292C032A66&sid=4D7D059FFBF006B9&eid=4FE459D71E3BF8EB&journal_id=0253-9772&journal_name=遗传&referenced_num=7&reference_num=16