%0 Journal Article
%T Analysis of Polymorphisms on Lewis Blood Group Antigen Related SE Gene in the Populations in Shandong with High-risk of Gastric Cancer and Beijing
山东临朐胃癌高发人群和北京人群Lewis血型抗原相关SE基因多态性分析 Analysis of Polymorphisms on Lewis Blood Group Antigen Related SE Gene in the Populations in Shandong with High-risk of Gastric Cancer and Beijing
%A Jin-Mai Jiang
%A Kai-Feng Pan
%A Jun-Ling Ma
%A Tao Ning
%A Gui-Rong Lu
%A Wei-Cheng You
%A Yang Ke
%A
姜劲迈
%A 潘凯枫
%A 马峻岭
%A 宁涛
%A 路桂荣
%A 游伟程
%A 柯杨JIANG Jin-Mai
%A PAN Kai-Feng
%A MA Jun-Ling
%A NING Tao
%A LU Gui-Rong
%A YOU Wei-Cheng
%A KE Yang
%J 遗传
%D 2003
%I
%X To study the relation between host genetic background and the susceptibility to H.pylori associated gastric cancer, PCR-sequencing and PCR-RFLP were used to screen SECRETOR gene polymorphisms in 142 subjects including 69 cancer patients and 73 non-cancer individuals from high-risk area of gastric cancer in Shandong and 93 control individuals from Beijing.Results showed that the difference in se(w)/se(w) distribution between non-cancer individuals and Beijing population was significant (P<0.01,OR is 3.06,95% CI,1.28-7.30), but that between cancer patients and non-cancer individuals was not with significance. SE gene polymorphism was not relevant to H.pylori infection. We concluded that Shandong population from high-risk area of gastric cancer shared a high distribution of se(w)/se(w) genotype,which could be considered as one of the genetic markers.
%K gastric cancer
%K Lewis blood group antigen
%K SECRETOR gene
%K gene polymorphism
山东临朐
%K 胃癌
%K 高发人群
%K 北京人群
%K Lewis血型抗原
%K SECRETOR基因
%K 基因多态性
%K 幽门螺杆菌
%K 遗传标记
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=27A138A1C8972594&yid=D43C4A19B2EE3C0A&vid=C5154311167311FE&iid=38B194292C032A66&sid=4D7D059FFBF006B9&eid=4FE459D71E3BF8EB&journal_id=0253-9772&journal_name=遗传&referenced_num=7&reference_num=16