%0 Journal Article
%T Mapping study of ankylosing spondylitis on HLA region in Jilin population of China<br>吉林人群强直性脊柱炎6号染色体短臂上的HLA区域遗传易感基因定位研究
%A WANG Ya-Wen
%A ZHU Xiao-Quan
%A SONG Yu-Guo
%A SUN Liang
%A YANG Ze
%A <br>王雅文
%A 朱小泉
%A 宋玉国
%A 孙亮
%A 杨泽
%J 遗传
%D 2007
%I 
%X To find the susceptible genes of ankylosing spondylitis in Chinese population, we select 11 SNPs on gene HLA gene family that has strong linkage of ankylosing spondylitis in 6p21.3. By case-control study in 79 AS patients and 132 healthy subjects, the distribution of TNF-alpha-850 genotype TT is higher in AS group than that in normal control group (P=0.027); Mutational allele T has a significant statistically difference between AS group and normal control group (P=0.002). By linkage disequilibrium study, there are 5 SNPs present the linkage disequilibrium and the region is 15 kb, including gene LTA, TNF-alpha, LST1 and NCR3; In the haplotypes of the 5 SNPs , the distribution of haplotype TCTTC has statistical difference between AS group and normal control group (chi2=7.406, P=0.0065), the haplotype contains mutational allele T of TNF-alpha-850. The result hints that there may be susceptible sites of AS in this 15 kb region, which may be TNF-alpha-850 C-->T mutation or other sites that around the TNF-alpha-850.
%K ankylosing spondylitis
%K susceptible gene
%K the frequency of genotype
%K linkage disequilibrium<br>强直性脊柱炎
%K 易感基因
%K 基因型频率
%K 连锁不平衡
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=5BA13D7BF066B0D6&yid=A732AF04DDA03BB3&vid=771469D9D58C34FF&iid=DF92D298D3FF1E6E&sid=8C8D39B86A1EED4F&eid=525CF7714FCB18E2&journal_id=0253-9772&journal_name=遗传&referenced_num=1&reference_num=22