%0 Journal Article
%T Finding finer functions for proteins related to breast cancer based on protein interaction network<br>根据蛋白质互作网络预测乳腺癌相关蛋白质的细致功能
%A WANG Jing
%A LI Yan-Hui
%A GUO Zheng
%A ZHU Jing
%A MA Wen-Cai
%A PENG Chun-Fang
%A LIU Qing
%A <br>王靖
%A 李彦辉
%A 郭政
%A 朱晶
%A 马文财
%A 彭春方
%A 刘庆
%J 遗传
%D 2007
%I 
%X Breast cancer is one of the most common malignant tumours. However, the existing functional knowledge about the proteins related to the breast cancer is too general to promote the following study. To find their finer functions, we suggest using the function-specific interaction sub-networks by integrating the functional knowledge of Gene Ontology and the protein-protein interaction network. The results show that the proposed approach is able to reliably find finer functions for these proteins with high precision. The predicted finer functions are highly valuable for guiding the follow-up wet-lab research to study the molecular mechanism of breast cancer.
%K breast cancer
%K protein function
%K prediction
%K interaction network
%K gene ontology<br>乳腺癌
%K 蛋白质功能
%K 预测
%K 互作网络
%K 基因本体
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=70043FB2684B389F&yid=A732AF04DDA03BB3&vid=771469D9D58C34FF&iid=9CF7A0430CBB2DFD&sid=29036368246435B2&eid=63025EFC6CC49145&journal_id=0253-9772&journal_name=遗传&referenced_num=1&reference_num=20