%0 Journal Article
%T Molecular Cloning and Characterization of a Novel Full-length cDNA Encoding Zinc Finger Protein of KRAB Type<br>一条KRAB型锌指蛋白全长新基因的克隆与功能初探 Molecular Cloning and Characterization of a Novel Full-length cDNA Encoding Zinc Finger Protein of KRAB Type
%A WANG Zhao
%A YING Kang
%A LIN Sheng-rong
%A WU Hai
%A XIE Yi
%A MAO Yu-min
%A <br>王兆
%A 应康
%A 林盛榕
%A 吴海
%A 谢毅
%A 毛裕民WANG Zhao
%A YING Kang
%A LIN Sheng-rong
%A WU Hai
%A XIE Yi
%A MAO Yu-min
%J 遗传
%D 2000
%I 
%X 从人胎脑ｃＤＮＡ库中克隆到一条全长的锌指蛋白新基因ｃＤＮＡ，命名为ＺＮＦ３０３。序列分析表明，ＺＮＦ３０３的Ｃ末端含有７个保守的锌指基序，Ｎ末端含有一个ＫＲＡＢ（Ｋｒｕｐｐｅｌ－ａｓｓｏｃｉａｔｅｄ ｂｏｘ）结构域。利用肝癌组织表达谱基因芯片杂交证明，该基因在肝癌组织中的表达量有明显降低。认为这种降低可能跟肝癌的形成和转移有密切的关系。利用辐射杂交基因定位技术，得出该基因在人类染色体上的位置是１
%K zinc finger protein
%K KRAB
%K hepatic cancer<br>锌指蛋白
%K KRAB
%K 肝癌
%K ZNF303
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=C15CF7059FB61D15&yid=9806D0D4EAA9BED3&vid=BC12EA701C895178&iid=E158A972A605785F&sid=002786F01A86D891&eid=4B1FFFA116F7AE3B&journal_id=0253-9772&journal_name=遗传&referenced_num=1&reference_num=0