%0 Journal Article
%T Progress in Research of Chitosan as a Non-viral Gene Delivery Vector<br>壳聚糖作为基因药物载体的研究进展
%A SU Hui-Shuang
%A WANG Yi-Fei
%A <br>苏惠霜
%A 王一飞
%J 遗传
%D 2006
%I 
%X Efficiency of non-viral gene delivery based on chitosan and chitosan derivatives as DNA condensing carrier is dependent on a series of factors, such as complex size, the charge ratio of chitosan/DNA, molecular mass of chitosan, the degree of chitosan deacetylation, pH and serum concentration of the transfection medium. Through modifying the chitosan in a certain extent, we can change the efficiency of transfection. Studies on transfection condition, efficiency and mechanism using chitosan and chitosan denvatives as transfection agents are reviewed.
%K chitosan
%K transfection
%K non-viral gene delivery
%K mechanism<br>壳聚糖
%K 转染
%K 基因载体
%K 机制
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=3E5B7249C1E44A08&yid=37904DC365DD7266&vid=D3E34374A0D77D7F&iid=F3090AE9B60B7ED1&sid=4882B246E68CA8CB&eid=8560D04B70E571A6&journal_id=0253-9772&journal_name=遗传&referenced_num=5&reference_num=17