%0 Journal Article
%T Latest advances of SLA classⅠgenes<br>SLAⅠ类基因研究新进展
%A TAO Xuan
%A LI Hua
%A LI Xue-Wei
%A YU Hui
%A ZUO Qi-Zhen
%A <br>陶璇
%A 李华
%A 李学伟
%A 于辉
%A 左启祯
%J 遗传
%D 2007
%I 
%X The Swine leukocyte antigen (SLA) class I genes encode multi-glycoproteins on cell surface, which present endogenous antigenic peptides to T cells and thus initiate specific immune responses. In this article, latest advances on molecular structure, expression in tissues, regulation of expression, genotyping, polymorphism, and evolution of SLA class I genes were introduced, in which genotyping and polymorphism were emphasized. Molecular typing methods of SLA class I genes include serological method, DNA sequencing, PCR-SSP, PCR-SSOP and MS, of which PCR-SSP is frequently used in genotyping of SLA class I genes as a simple and rapid method. Future directions for the study and application of SLA class I genes on gene functions, peptide vaccine, xenotransplantation were also discussed.
%K SLAⅠ类基因
%K 表达
%K 多态性
%K 进化
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=00485C538484E5ED3493FFCEAC53F9DB&yid=A732AF04DDA03BB3&vid=771469D9D58C34FF&iid=708DD6B15D2464E8&sid=A2484BFF38B01808&eid=525C740F5A062BF4&journal_id=0253-9772&journal_name=遗传&referenced_num=0&reference_num=44