%0 Journal Article
%T Mitochondrial DNA mutations and related human dis-eases<br>线粒体DNA突变与相关人类疾病
%A CHEN Gang
%A DU Wei-Dong
%A CAO Hui-Min
%A <br>陈刚
%A 杜卫东
%A 曹慧敏
%J 遗传
%D 2007
%I 
%X In the past two decades, it has been found that mitochondrial DNA (mtDNA) mutations are associated with a wide range of human diseases, from those affecting single organ to those with multi-system involvement. The purpose of this review is to explore the relationship between mtDNA mutations and human diseases. Four aspects are highlighted: characteristics of mitochondrial genetics, mtDNA mutations in human inherited diseases, role of somatic mtDNA mutations in aging and tumor, as well as diagnosis and treatment of mtDNA diseases.
%K mitochondrial diseases
%K mitochondrial DNA
%K mutation
%K diagnosis<br>线粒体疾病
%K 线粒体DNA
%K 突变
%K 诊断
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=00485C538484E5ED7A8FC27B84EF8C8E&yid=A732AF04DDA03BB3&vid=771469D9D58C34FF&iid=708DD6B15D2464E8&sid=74FE4F3839E9253E&eid=9A66D940867B74F7&journal_id=0253-9772&journal_name=遗传&referenced_num=1&reference_num=60