%0 Journal Article
%T Analysis of genetic variations at M857 locus of the a1-Fucosy- trans-ferase (FUT1) ORF in pigs<br>猪a1-岩藻糖转移酶基因(FUT1) M857位点遗传变异分析
%A WU Sheng-Long
%A BAO Wen-Bin
%A JU Hui-Ping
%A ZHU Guo-Qiang
%A LI Bi-Chun
%A CHEN Guo-Hong
%A <br>吴圣龙
%A 包文斌
%A 鞠慧萍
%A 朱国强
%A 李碧春
%A 陈国宏
%J 遗传
%D 2007
%I 
%X Enterotoxigenic Escherichia coli F18 (ETEC F18) is the main pathogen that causes edema disease and post-weaning diarrhea in piglets,and a1-fucosytransferase (FUT1) gene has been identified as a receptor gene encoding the receptor for ETEC F18 bacteria. In this study,the method of PCR-RFLP was used to investigate the among 21 breeds in-cluding one wild boar breed and 20 western commercial and Chinese native pig breeds (populations). The results showed that none of the individuals in all 21 breeds possessed the resistant AA genotype,the genetic polymorphisms of the FUT1 locus were only detected in two western pig breeds (Duroc and Yorkshire),Lingao pig and hybrid pig breeds,while the wild boar and all the other Chinese pig breeds only possessed the susceptible GG genotype. The results indicated that Chinese native pig breeds,unlike western pig breeds,lack the genetic background on the resistance to ETEC F18 bacteria. This may be owe to their different origination,as the resistance gene to ETEC F18 might be originated from European wild boar. It was also inferred that edema disease and post-weaning diarrhea caused by ETEC F18 had close relationship with the growth speed of pigs.
%K Escherichia coli F18
%K FUT1 gene
%K genetic variation<br>大肠杆菌F18
%K FUT1基因
%K 遗传变异
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=EEB98ED550FE0251&yid=A732AF04DDA03BB3&vid=771469D9D58C34FF&iid=9CF7A0430CBB2DFD&sid=5DD55A2029F498FE&eid=BB5084A31068995F&journal_id=0253-9772&journal_name=遗传&referenced_num=1&reference_num=14