%0 Journal Article
%T Analysis of apolipoprotein A5 gene polymorphisms in Hubei Han people<br>湖北汉族人群载脂蛋白A5遗传多态性分析
%A DING Yan
%A ZHU Ming-An
%A ZHOU You-Li
%A WANG Zhi-Xiao
%A YANG Gong-Li
%A <br>丁妍
%A 朱名安
%A 周有利
%A 王治校
%A 杨公利
%J 遗传
%D 2007
%I 
%X Polymerase chain reaction-restriction fragments length polymorphism (PCR-RFLP) was used to explore the distribution of apolipoprotein A5 gene-1131T>C and 56C>G polymorphisms in 257 healthy Hubei Han people. The following results were calculated: the frequency of-1131TT genotype was 50.9%, far more than that of ?1131TC and ?1131CC genotypes (32.9% and 16.2%, respectively). The number of T allele carriers was higher than that of C carriers, and their respective frequencies were 0.675 and 0.325. There were 56GG and 56GC genotypes, but only 2 individuals in all subjects carried the G allele, the frequency of which was low than 5%. Furthermore, the frequency of genotypes and alleles in apoa5 ?1131T>C and 56C>G polymorphisms was clearly different from other races and areas. We conclude that the apoa5 ?1131T>C variation should be considered a single nucleotide polymorphism, but the 56C>G variation should be considered as a mutation instead.
%K apolipoprotein A5
%K gene polymorphism
%K triglyceride
%K genotype<br>载脂蛋白A5
%K 基因多态性
%K 甘油三酯
%K 基因型
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=330821A0845AC0DD&yid=A732AF04DDA03BB3&vid=771469D9D58C34FF&iid=94C357A881DFC066&sid=D8414BC1307BF1A3&eid=C7A2B92569DF5458&journal_id=0253-9772&journal_name=遗传&referenced_num=1&reference_num=12