%0 Journal Article
%T A Study of Insertion/Delation Polymorphism of the Angiotensin-Converting Enzyme Gene in Pilots<br>飞行员中血管紧张素转换酶基因插入或缺失多态性研究 A Study of Insertion/Delation Polymorphism of the Angiotensin-Converting Enzyme Gene in Pilots
%A CAI Qing
%A LIU Hong-jin
%A ZHU Mei-cai
%A JIANG Shu-qiang
%A WANG Yin-jing
%A ZHAN Zhi
%A JIANG Jian-dong
%A <br>蔡庆
%A 刘红巾
%A 朱美财
%A 姜树强
%A 王荫静
%A 占志
%A 姜建东CAI Qing
%A LIU Hong-jin
%A ZHU Mei-cai
%A JIANG Shu-qiang
%A WANG Yin-jing
%A ZHAN Zhi
%A JIANG Jian-dong
%J 遗传
%D 2002
%I 
%X In order to understand insertion/delation (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in pilots,and to explore the relationship between ACE gene I/D polymorphism and the perfomance of the pilots,the polymerase chain reaction (PCR) was used to determine the genotypes for an I/D polymorphism in intron 16 of the ACE gene in 118 pilots and 96 healthy subjects as controls.The result showed that the I/D polymorphism in intron 16 of the ACE gene was categorized into three genotypes: two deletion alleles (genotype DD),heterozygous alleles (genotype ID),and two insertion alleles (genotype II).The genotype II and I allele frequency were significantly higher in pilots (44.07% and 0.65) than that in healthy subjects (31.25% and 0.52).It is suggested that I gene of ACE may play a role in perfomance of the pilots.
%K angiotensin-converting enzyme
%K gene polymorphism
%K pliot<br>血管紧张素转换酶
%K 基因多态性
%K 飞行员
%K 基因缺失
%K 飞行耐力
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=102944AF7D4B00F6&yid=C3ACC247184A22C1&vid=B91E8C6D6FE990DB&iid=CA4FD0336C81A37A&sid=B31275AF3241DB2D&eid=5D311CA918CA9A03&journal_id=0253-9772&journal_name=遗传&referenced_num=4&reference_num=8