%0 Journal Article
%T 筛选机制与细胞衰老的DNA损伤假说 Selective Mechanisms and the DNA Injury Hypothesis of Cell Senescence
%A 陈作舟CHEN
%A Zuo-zhou
%J 遗传
%D 2001
%I 
%X 生物界存在一类筛选机制,它将DNA损伤较小的细胞筛选出来,产生后代.主要有两类模式机制1和机制2,分别以细菌和人的成纤维细胞为代表,那些具有筛选机制1的细胞(如:细菌、生殖细胞、癌细胞)能无限传代,而体细胞则不能.这两类筛选机制背后有更深刻的原因,而细胞的癌变正是从机制2退化为机制1的过程。 Abstract:Selective mechanisms exist in organism and biosphere,which select the cells with less DNA injuy and reproduces them.There are two models;Mechanisms 1 and Mechanisms 2,represented respectively b bacteria and mechanolytes of human beings.Cells with Mechanisms 1(e.g. bacteria,generative cells,cancer cells)can reproduce infinitely,while somatic cells can not.There are deep-going reasons behind the two categories of selective mechanisms.The canceration of the cells is a degenerating process from Mechanisms 2 to Mechanisms 1.
%K 筛选机制
%K 细胞衰老
%K DNA损伤
%K 凋亡
%K Key
%K words
%K selective
%K mechanisms
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=9EC46FC43A1DD8EE830C958107B40C91&yid=14E7EF987E4155E6&vid=EA389574707BDED3&iid=B31275AF3241DB2D&sid=8966A0F1B07BE5EE&eid=556C1A86E372B606&journal_id=0253-9772&journal_name=遗传&referenced_num=0&reference_num=0