%0 Journal Article
%T Advances on Inhibin Genes<br>抑制素基因的研究进展Advances on Inhibin Genes
%A XUE Yu
%A CHU Ming-Xing
%A ZHOU Zhong-Xiao
%A <br>薛 昱
%A 储明星
%A 周忠孝XUE Yu
%A CHU Ming-Xing
%A ZHOU Zhong-Xiao
%J 遗传
%D 2004
%I 
%X Inhibins are gonadal glycoprotein hormones belonging to the transforming growth factor-beta superfamily that act to suppress pituitary follicle-stimulating hormone synthesis and secretion. In this paper, we briefly introduced the cloning, structure, localization, polymorphism, expression, molecular regulation of inhibin-alpha(INHA), -betaA (INHBA) and -beta B (INHBB) subunit genes and their relationships with reproductive performance and cancer. The inhibin genes (INHA, INHBA and INHBB) had significant effect on litter size in sheep. The ovine INHA, INHBA and INHBB genes had been mapped to chromosomes 2q41-->q43, 4q26 and 2q31-->q33, respectively. The female mice carrying INHBB mutations suffered from distinct developmental and reproductive defects. The INHA gene was significantly associated with premature ovarian failure in women.
%K inhibin
%K inhibin gene
%K reproductive performance
%K cancer<br>抑制素
%K 抑制素基因
%K 繁殖性能
%K 癌症
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=5FE2EC1A57D48074&yid=D0E58B75BFD8E51C&vid=96C778EE049EE47D&iid=94C357A881DFC066&sid=762CFFBBDED11937&eid=B37ED91D1227CC95&journal_id=0253-9772&journal_name=遗传&referenced_num=10&reference_num=51