%0 Journal Article
%T 生物芯片技术的原理与应用 The Principle and Application of Bio - Chip Technology
%A 池晓菲
%A 舒庆尧CHI Xiao-fei
%A SHU Qing-yao
%J 遗传
%D 2001
%I 
%X 生物芯片是指将大量生物讯息密码(寡核苷酸、cDNA、基因组DNA、蛋白质等)以预先设计的方式固定在玻片、硅片等固相载体上组成的密集分子阵列,可分为核酸芯片、蛋白芯片、芯片实验室三类.生物芯片技术的本质是生物信号的平行分析,它利用核酸分子杂交、蛋白分子亲和原理,通过荧光标记技术检测杂交或亲和与否,可迅速获得所需信息.高效、快速的生物芯片技术以其无与伦比的优势,已在医学、分子生物学等领域显现出巨大的应用价值,具有非常广阔的发展前景。 Abstract:Bio-chip is a molecular micro-array,which is composed of some biological message codes (e.g.ohgonucleotides,cDNA,genome DNA,protein,and so on) arranged on solid surfaces in light of a engineering design in advance.There are three kinds of Bio-Chips,i.e.,nucleic acid chip,protein chip,and chip “lab”.The essence of Bio-Chip technology is a parallel analysis for biology message.It is based on the principle of nucleic acid molecule hybridization or protein immunochemistry.The occurrence of hybridization/immunoreaction is detected by fluo-labelled technology.Then the needed message can quickly be obtained.Efficient and fast Bio-Chip technology has already exhibited enormous applied value in medical science and molecule biology field because of incomparable superority.M
%K 生物芯片
%K 核酸芯片
%K 蛋白芯片
%K 芯片实验室
%K 荧光标记技术
%K Key
%K words
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=FBC73E5AFC6C1FCDDEF8B940471E3491&yid=14E7EF987E4155E6&vid=EA389574707BDED3&iid=E158A972A605785F&sid=0918129209B14F3E&eid=93661EC4C0CCEA67&journal_id=0253-9772&journal_name=遗传&referenced_num=0&reference_num=0