%0 Journal Article
%T A Study on Mutation of p53 Gene in Colorectal Cancer<br>大肠癌中p53基因突变的研究 A Study on Mutation of p53 Gene in Colorectal Cancer
%A Wu Guojun
%A Li Mingfa
%A Shan Xiangnian
%A Yu Long
%A Zhao Shouyuan
%A <br>吴国俊
%A 李明发
%A 单祥年
%A 余龙
%A 赵寿元WU Guo-Jun
%A LI Ming-Fa
%A SHAN Xiang-Nian
%A YU Long
%A ZHAO Shou-Yuan
%J 遗传
%D 1996
%I 
%X The exons 4-7 of p53 gcne were examined in 14 colorectal Cancer patients by using PCR SSCP-silver staining method. The results showed 6 cases of point mutation and the mutation frcquencies of exons were differcnt from each other. p53 cDNA and pYNZ22 VNTR were used as probes to examine LoH(Loss of hctcrozygosity) of 14 co1orcctal cancers. 6 cases with LOH were found. The results of present rcscarch suggest that the mutation and LOH of p53 gene are critical events in the progress and develop ment of Cancer. There werc different kinds of inactivation model of p53 gene in the process of develop ment of cancer and transformation of cells.
%K Colorectal cancer
%K p53 gene
%K SSCP
%K LOH<br>大肠癌
%K p53基因
%K 单链构型多态性
%K 杂合性丢失
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=2F3F9D1C0B064B8DCD508678F76E2E3F&yid=8A15F8B0AA0E5323&vid=13553B2D12F347E8&iid=E158A972A605785F&sid=96C778EE049EE47D&eid=D3E34374A0D77D7F&journal_id=0253-9772&journal_name=遗传&referenced_num=2&reference_num=1