%0 Journal Article
%T Involvement of N-methyl-D-aspartate Receptors in Stress-Induced Behavioral Changes<br>中枢N-甲基-D-天冬氨酸受体在应激所致行为改变中的作用
%A Li Huanhuan
%A Lin Wenjuan
%A <br>李欢欢
%A 林文娟
%J 心理科学进展
%D 2005
%I 
%X Studies in the physiological psychology field have been focused on the brain mechanisms underlying stress-induced behavioral changes. The role of NMDA receptor (NR) in mediating stress-induced behavioral changes has gained more and more attention. NR is important for synaptic plasticity, brain development, and learning and memory. It has been shown that different stressors up-regulate the level or activity of NR in some brain regions, such as hippocampus and amygdale. Injection of the NR antagonist into these regions prior to stress can reduce stress-induced anxiety and depression, suggesting that NR are important mediators of stress-induced behavioral changes. N-methyl-D-aspartate receptors are important substance related closely with stress response and participate the process of brain damage caused by stress. N-methyl-D-aspartate receptor antagonists may be useful for treatment of stress-related mental disorder, such as recurrent depression, posttraumatic stress disorder. Furthermore, studies on neurogranin, a downstream signal molecule in NR-dependant transduction pathway, provided further information about the mechanisms underlying the effects of stress on behavior.
%K N-methyl-D-aspartate receptor
%K neurogranin
%K stress
%K behavior<br>NMDAR
%K 应激
%K 行为
%K 神经颗粒素
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=C94E3F05CFD5644C9DAA97BEB9148D4784B6B22E64D84F4E&jid=FAB1670F77CCC8EC7D836E0D41B12069&aid=D7B0312145EAE2BF&yid=2DD7160C83D0ACED&vid=FC0714F8D2EB605D&iid=38B194292C032A66&sid=CA9ED1AB4D9E3E04&eid=377D325742940769&journal_id=1671-3710&journal_name=心理科学进展&referenced_num=2&reference_num=31