%0 Journal Article
%T The Animal Model of Stress-induced Relapse and Its Neurobiological Mechanisms<br>应激诱发复吸的动物模型及其神经生物学基础
%A Yu Bin
%A Wang Jia
%A Li Xinwang
%A <br>于斌
%A 王佳
%A 李新旺
%J 心理科学进展
%D 2006
%I 
%X Relapse is a major characteristic of drug addiction disorders and it has been well established that stress induces reinstatement of drug seeking in the animal model of relapse. This article first briefly describes several animal models that have been used to study the reinstatement of drug seeking induced by stress. Then it reviews evidence from studies concerned with the neurobiological mechanisms involved in stress-induced reinstatement of drug seeking. The results of these studies suggest an important role of the brain corticotrophin-releasing factor (CRF) and noradrenaline (NA) neurons of the amygdala and the bed nucleus of the stria terminalis (BNST) in the modulation of stress-induced reinstatement. The medial prefrontal cortex (mPFC) region may be a common pathway for cue, drug and stress-induced reinstatement of drug seeking.
%K relapse
%K stress
%K reinstatement model
%K corticotrophin-releasing factor (CRF)
%K noradrenaline (NA)<br>复吸
%K 应激
%K 恢复模型
%K 促肾上腺皮质激素释放因子
%K 去甲肾上腺素
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=C94E3F05CFD5644C9DAA97BEB9148D4784B6B22E64D84F4E&jid=FAB1670F77CCC8EC7D836E0D41B12069&aid=BDFB582DA2A2CCE0&yid=37904DC365DD7266&vid=F3583C8E78166B9E&iid=CA4FD0336C81A37A&sid=A4FA325EA800C820&eid=DBF54A8E2A721A6D&journal_id=1671-3710&journal_name=心理科学进展&referenced_num=0&reference_num=30