%0 Journal Article
%T THE SYNAPTIC MECHANISM OF SCOPOLAMINE-INDUCED MEMORY DYSFUNCTION IN THE BRAIN<br>东莨菪碱所致记忆障碍的脑内突触机制
%A Zhang Zigui Xu Xiaohong
%A <br>章子贵
%A 徐晓虹
%A 吴馥梅
%J 心理学报
%D 1998
%I 
%X In this study the synaptic mechanism of scopolamine-induced memory dysfunctionwas investigated in the brain,the changes of the structure parameters of Gray Isynaptic interface in the hippocampal CA3 area were quantitatively analyzed in micemodel of scopolamine-induced memory dysfunction,and the effect of scopolamine onthe incorporation of3 H-Leu into hippocampal symaptosomes was observed.The resultsshowed that scopolamine could induce the thickness of post-synaptic density (PSD)thinned down significantly(P<0.01),and reduced the incorporation of 3 H-Leu intohippocampal symaptosomes apparently (p<0.001).These results suggested that thescopolamine-included memory dysfunction may be based on the decrease ofsynaptosomal protein syntheses of cholinergic system,and the changes of the synapticstructural parameters in the brain.
%K 东莨菪碱
%K 衰老性
%K 老年人
%K 记忆障碍
%K 突触结构参数
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=C94E3F05CFD5644C9DAA97BEB9148D4784B6B22E64D84F4E&jid=1EE72F392B87F45015B3CA6D9A7AFA6F&aid=B45572E9B63ED587856B8D23267047AA&yid=8CAA3A429E3EA654&vid=4AD960B5AD2D111A&iid=38B194292C032A66&sid=2E01F39B6CBD53DE&eid=50EA2A80A7D254EF&journal_id=0439-755X&journal_name=心理学报&referenced_num=17&reference_num=7