%0 Journal Article
%T CORRELATION BETWEEN LEARNING-MEMORY AND THE CEREBRAL SYNAPTIC STRUCTURAL PARAMETERS IN MICE<br>小鼠的记忆与脑内突触结构参数变化的相关性
%A Zhang Zigui
%A Du Hongyan
%A Lu Hanxin
%A <br>章子贵
%A 杜红燕
%A 陆汉新
%J 心理学报
%D 1995
%I 
%X This study investigated the correlation between learning-memory capacity of different month-aged mice and their central synaptic structural parameters.The discrimination learning capacity was tested by Y-maze and memory retention was observed by using one trial passive avoidance response in both 1-month and 6-month aged mice respectively.Then the animals were killed and the hippocampus and sensori-motor areas of the cerebral cortex were prepared for electron microscopy.The electron microphotographs were analysed quantitatively by XY-biological image analysis system.The main results were as follows:(1)The descrimination learning capacity of 1-month aged mice were significantly better than that of the 6-month aged mice(p<0.05),while memory retention of 1-month aged mice was slightly superior to that of the 6-month aged mice.(2)The curvatures of synaptic interface of 6-month aged mice were greater that of the 1-month aged mice(p<0.05 in the sensori-motor areas:p<0.01 in the hippocampus),while the PSDs of 6-month aged mice were less than that of the 1-month aged mice(p<0.01).These results suggested that changes of learning-memory capacity with increasing age may be based on the changes of the structure of synaptic interface in the brain of mice.
%K synaptic structural parameters
%K CA3 area of hippocampus
%K sensori-motor area of cortex
%K electron microscopy
%K mice<br>突触结构参数
%K 海马CA3区
%K 小鼠
%K 记忆
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=C94E3F05CFD5644C9DAA97BEB9148D4784B6B22E64D84F4E&jid=1EE72F392B87F45015B3CA6D9A7AFA6F&aid=08C3C0B9E93F9D04590D93365AFDC601&yid=BBCD5003575B2B5F&vid=D3E34374A0D77D7F&iid=38B194292C032A66&sid=E3094127AA4ABC1A&eid=4AD4BA66429F5627&journal_id=0439-755X&journal_name=心理学报&referenced_num=10&reference_num=0