%0 Journal Article
%T Macrophage LRP1 Suppresses Neo-Intima Formation during Vascular Remodeling by Modulating the TGF-¦Â Signaling Pathway
%A Selen Catania Muratoglu
%A Shani Belgrave
%A Anna P. Lillis
%A Mary Migliorini
%A Susan Robinson
%A Elizabeth Smith
%A Li Zhang
%A Dudley K. Strickland
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0028846
%X Vascular remodeling in response to alterations in blood flow has been shown to modulate the formation of neo-intima. This process results from a proliferative response of vascular smooth muscle cells and is influenced by macrophages, which potentiate the development of the intima. The LDL receptor-related protein 1 (LRP1) is a large endocytic and signaling receptor that recognizes a number of ligands including apoE-containing lipoproteins, proteases and protease-inhibitor complexes. Macrophage LRP1 is known to influence the development of atherosclerosis, but its role in vascular remodeling has not been investigated.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028846