%0 Journal Article
%T Autocrine Prostaglandin E2 Signaling Promotes Tumor Cell Survival and Proliferation in Childhood Neuroblastoma
%A Agnes Rasmuson
%A Anna Kock
%A Ole Martin Fuskev£¿g
%A Bj£¿rn Kruspig
%A Jaione Sim¨®n-Santamar¨ªa
%A Vladimir Gogvadze
%A John Inge Johnsen
%A Per Kogner
%A Baldur Sveinbj£¿rnsson
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0029331
%X Prostaglandin E2 (PGE2) is an important mediator in tumor-promoting inflammation. High expression of cyclooxygenase-2 (COX-2) has been detected in the embryonic childhood tumor neuroblastoma, and treatment with COX inhibitors significantly reduces tumor growth. Here, we have investigated the significance of a high COX-2 expression in neuroblastoma by analysis of PGE2 production, the expression pattern and localization of PGE2 receptors and intracellular signal transduction pathways activated by PGE2.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029331