%0 Journal Article %T Autocrine Prostaglandin E2 Signaling Promotes Tumor Cell Survival and Proliferation in Childhood Neuroblastoma %A Agnes Rasmuson %A Anna Kock %A Ole Martin Fuskev£¿g %A Bj£¿rn Kruspig %A Jaione Sim¨®n-Santamar¨ªa %A Vladimir Gogvadze %A John Inge Johnsen %A Per Kogner %A Baldur Sveinbj£¿rnsson %J PLOS ONE %D 2012 %I Public Library of Science (PLoS) %R 10.1371/journal.pone.0029331 %X Prostaglandin E2 (PGE2) is an important mediator in tumor-promoting inflammation. High expression of cyclooxygenase-2 (COX-2) has been detected in the embryonic childhood tumor neuroblastoma, and treatment with COX inhibitors significantly reduces tumor growth. Here, we have investigated the significance of a high COX-2 expression in neuroblastoma by analysis of PGE2 production, the expression pattern and localization of PGE2 receptors and intracellular signal transduction pathways activated by PGE2. %U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029331