%0 Journal Article
%T Damaging Effects of Nanosized TiO2 on Bel-7402 Human Liver Cancer Cell Under Photoinduce<br>纳米TiO2光诱导杀伤 Bel-7402人体肝癌细胞研究
%A XIA Chun-Hui
%A WANG Bai-Qi
%A WANG Yu
%A LIU Ya-Qin
%A XU Guang-You
%A WU Shan
%A <br>夏春辉
%A 王百齐
%A 王玉
%A 刘亚琴
%A 徐广有
%A 吴山
%J 无机材料学报
%D 2006
%I Science Press
%X The damaging effects of nanosized TiO_2 on human Bel-7402 liver cancer cell were investigated by means of HE dye method and MTT colorimetric assay under condition of photoin- duce.The influences of nanosized TiO_2 content,and irradiation time on cancer inhibition were systematically studied,and the inhibition mechanism was primarily discussed.The results show that nanosized TiO_2 exhibits good inhibition effects under appropriate TiO_2 concentration,and the inhibition process obeys first order reaction rule approximately;In addition,activity oxygen produced by nanosized TiO_2 under illumination can react with organicmolecules in and out the cancer cell membrane,so that lead to damage cell structure,result into imbalance of Ca~(2+) in the cancer cell,and induce microtubule reassembly due to expression changes of microtubule-associated protein-2,which are responsible for the apoptotic and dead cancer cells.
%K MAP-2<br>纳米TiO2
%K 光诱导杀伤
%K 肝癌细胞
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=84529CA2B2E519AC&jid=ABC0063016AF57E1C73EF43C8D2212BD&aid=D8A90E4679D5F19B&yid=37904DC365DD7266&vid=659D3B06EBF534A7&iid=B31275AF3241DB2D&sid=9BE3F470BE08362E&eid=4BA709A0F998E415&journal_id=1000-324X&journal_name=无机材料学报&referenced_num=0&reference_num=17