%0 Journal Article
%T A new method of rigid-body refinement for protein crystal structures<br>蛋白质晶体结构刚体优化的新方法
%A Ding Wei
%A Jiang Fan
%A <br>丁玮
%A 江凡
%J 物理学报
%D 2011
%I 
%X A new rigid-body refinement method for protein crystal structures is described. It is based on "Variable Metric Methods in Multidimensions" and "the Electron Density Map Correlation Coefficient". Test shows that the orientation and translation of the initial models can be improved effectively by this new method. And it can escape from the local extremum and reach the global optimum more easily than the maximum likelihood method when the search space has a large number of local extremum points.
%K protein crystal structures
%K rigid-body refinement
%K variable metric methods in multidimensions
%K the electron density map correlation coefficient<br>蛋白质晶体结构
%K 刚体优化
%K 多元函数的变尺度方法
%K 电子密度图的相关系数
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=47EA7CFDDEBB28E0&jid=29DF2CB55EF687E7EFA80DFD4B978260&aid=39B0D9DC772D1F73268BDDF65555C4E8&yid=9377ED8094509821&vid=BFE7933E5EEA150D&iid=E158A972A605785F&sid=5824536C90612D67&eid=A6683C8C0EB9BCA7&journal_id=1000-3290&journal_name=物理学报&referenced_num=0&reference_num=24