%0 Journal Article
%T Photoacoustic angiography for mouse brain cortex using near-infrared light<br>利用近红外光激发的光声血管造影成像
%A Yang Si-Hua
%A Yin Guang-Zhi
%A <br>杨思华
%A 阴广志
%J 物理学报
%D 2009
%I 
%X Photoacoustic imaging is a novel noninvasive imaging technique of biological tissue that overcomes the overwhelming scattering of light in biological tissue by utilizing ultrasonic wave to translate the image signal. In this study, near-infrared light and indocyanine green as an optical contrast agent were used to achieve the cerebrovascular distribution by photoacoustic imaging. Near-infrared light penetrates deep into the brain tissues through the skin and skull, and the indocyanine green enhances the photoacoustic signals of the blood vessels. A photoacoustic angiography of vascular distribution in the mouse brain in vivo was acquired that matches the anatomical photograph well. The experimental result demonstrates the photoacoustic imaging with near-infrared light and optical contrast agent has the potential for functional and molecular biomedical imaging.
%K photoacoustic imaging
%K near-infrared contrast agent
%K angiography
%K photoaconstic signal<br>光声成像，
%K 光吸收增强剂，
%K 血管造影，
%K 光声信号
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=47EA7CFDDEBB28E0&jid=29DF2CB55EF687E7EFA80DFD4B978260&aid=DA3336B8FF8439A6537B842CDFE6B9B4&yid=DE12191FBD62783C&vid=9FFCC7AF50CAEBF7&iid=DF92D298D3FF1E6E&sid=9747AF8767520069&eid=C0B40079726594F4&journal_id=1000-3290&journal_name=物理学报&referenced_num=1&reference_num=0