%0 Journal Article
%T A dynamical model of DNA-damage derived p53-Mdm2 interaction<br>DNA损伤致p53-Mdm2相互作用的动力学模型
%A Zhang Li-Juan
%A Yan Shi-Wei
%A Zhuo Yi-Zhong
%A <br>张丽娟
%A 晏世伟
%A 卓益忠
%J 物理学报
%D 2007
%I 
%X The recent experiments on the dynamics of a common biological network motif, p53-Mdm2 feedback loop in population and individual cells shows two different kinds of oscillatory behaviors, namely the damped and sustained oscillations, for the activities of p53 and Mdm2 proteins in response to DNA damage. By exploiting the nonlinear dynamics in the negative feedback loop and through analyzing the dynamical relation between the DNA damage and the activities of p53 and Mdm2 proteins, we propose a nonlinear dynamical model to describe the oscillatory behaviors for the activities of p53 and Mdm2 proteins both in individual and in population of cells in a self-consistent and unified way.
%K p53-Mdm2 negative feedback loop
%K sustained and damped oscillations
%K nonlinear dynamical model<br>p53-Mdm2负反馈回路
%K 非衰减振荡和衰减振荡
%K 非线性动力学模型
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=47EA7CFDDEBB28E0&jid=29DF2CB55EF687E7EFA80DFD4B978260&aid=AFAE99A363DBEAB7&yid=A732AF04DDA03BB3&vid=014B591DF029732F&iid=E158A972A605785F&sid=270C3D88FF95CF50&eid=E1C376F02A93ABE6&journal_id=1000-3290&journal_name=物理学报&referenced_num=0&reference_num=17