%0 Journal Article
%T Antibacterial Activity of Sponge Associated Marine Bacterium Pseudaltero-monas sp.NJ6-3-1 Regulated by Quorum Sensing<br>海绵共栖细菌NJ6-3-1基于群体感应调控的抗菌活性
%A Xiuchun Guo
%A Li Zheng
%A Zhisong Cui
%A Ping Han
%A Li Tian
%A Xiaoru Wang
%A <br>郭秀春
%A 郑立
%A 崔志松
%A 韩平
%A 田黎
%A 王小如
%J 微生物学报
%D 2008
%I 
%X Objective] We chose a sponge-associated marine-bacterium Pseudoalteromonas piscicida NJ6-3-1 to study whether its antibacterial activity were regulated by quorum sensing. Methods] We studied the relationship between the antibacterial activity and bacterial density under various growth conditions. To simulate the natural competitive environment, we monitored the antibacterial activity at low cell density when the species were co-cultured with Staphylococcus aureus. Results] Antibacterial activity correlated closely with cell density. Marine bacterium NJ6-3-1 started producing antibacterial compounds when cell density reached the threshold value of OD630=0.4. Some signal molecules existing in the metabolites of S. aureus could induce the production of antibacterial substance by marine-bacteria NJ6-3-1 even cell density below the required threshold. Conclusion] The results provide preliminary evidence to support the hypothesis that the antibacterial activity of NJ6-3-1 was regulated by the quorum sensing system of intraspecies and interspecies.
%K quorum sensing
%K marine bacterium
%K autoinducer
%K antibacterial activity<br>群体感应
%K 海洋细菌
%K 自体诱导物
%K 抗菌活性
%K 海绵
%K 共栖
%K 细菌
%K 群体感应
%K 调控
%K 抗菌活性
%K Bacterium
%K Marine
%K Associated
%K Sponge
%K Activity
%K Antibacterial
%K 感应系统
%K 信号分子
%K 存在
%K 代谢产物
%K 病原菌
%K 阈值
%K 相关
%K 行为
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=121B27E8F23C0C900C7D773B9334E286&yid=67289AFF6305E306&vid=B6DA1AC076E37400&iid=E158A972A605785F&sid=6313C162FF75889A&eid=64808317C39DF331&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=34