%0 Journal Article
%T Capsular saliva acid of Streptococcus suis 2 influences virulence and host inflammatory responses<br>猪链球菌2型荚膜唾液酸对细菌毒力和宿主炎症反应的影响
%A Jie Shi
%A Dan Hu
%A Jing Zhu
%A Xianyun Zhang
%A Tianqing Hou
%A Jingjing Guo
%A Xiuzhen Pan
%A Xianfu Li
%A Changjun Wang
%A <br>石洁
%A 胡丹
%A 朱静
%A 张先云
%A 侯田青
%A 郭静静
%A 潘秀珍
%A 李先富
%A 王长军
%J 微生物学报
%D 2012
%I 
%X Objective] We clarified the pathogenic influence of the absence of Streptococcus suis type 2 capsular saliva acid on BLAB/c mice.Methods] The virulence of the experimental strains were compared;the distribution of strains in vivo was determined by quantitative plating.Histopathological analysis was used to qualitatively compare the different pathogenicity of wild strain and knockout strains.ELISA was used to test the levels of cytokine in whole blood cells for the stimulation of strains.Results] The virulence of mutant strains was significantly reduced,and when the genes were restored,toxicity levels were recovered to that of the wild type strain.The distribution in blood and in the brain between wild strain and knock out strains has significant difference,and Streptococcus suis type 2 strains can cause different degrees of brain damage.During the in vitro test,the mutant strains can stimulate the whole blood cells to secrete higher levels of MCP-1 and IL-6.Conclusion] Capsular saliva acid affects bacterial virulence and host cell inflammation response.As an important virulence factor of Streptococcus suis type 2,it can damage the blood brain barrier and cause meningitis.
%K Streptococcus suis 2
%K capsule
%K sialic acid
%K virulence
%K cytokine<br>猪链球菌2型
%K 荚膜
%K 唾液酸
%K 毒力
%K 炎症因子
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=9FDF75195748F95DA1C228B2EB96AB2A&yid=99E9153A83D4CB11&vid=286FB2D22CF8D013&iid=E158A972A605785F&sid=E3C3E274D87A8C16&eid=9B1D77939DDB4B89&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=0