%0 Journal Article
%T Microbial NAD synthetase and its inhibitors - A review<br>微生物NAD合成酶及其抑制剂的研究进展
%A Jicai Bi
%A Honghai Wang
%A Jianping Xie
%A <br>毕继才
%A 王洪海
%A 谢建平
%J 微生物学报
%D 2011
%I 
%X Abstract: Nicotinamide - adenine dinucleotide (phosphate) (NAD(P)) metabolism involves many fundamental cellular events, such as energy metabolism, maintenance of redox homeostasis and regulation of cell longevity. Inhibitors of essential enzymes of NAD(P) biosynthetic pathways might be promising leads for novel antibiotics, such as the NAD synthase inhibitors. This review described the crystal structural, functional properties, regulator and structure-based inhibitors design for NAD synthase. This might provide the basis for developing NAD-based therapeutics.
%K Keywords: biosynthesis technology
%K nanomaterials
%K microorganism<br>关键字：Ⅵ型分泌系统，结构，功能，调控
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=BD9B3C798DF5CBBC48FFB666FFA9B8DF&yid=9377ED8094509821&vid=987EDA49D8A7A635&iid=38B194292C032A66&sid=407C905D8F0449C4&eid=7737D2F848706113&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=26