%0 Journal Article
%T Bacterial spore-a new vaccine vehicle-A Review<br>细菌芽胞—— 一种新型的疫苗载体
%A Yanchun Wang
%A Zhaoshan Zhang
%A <br>王艳春
%A 张兆山
%J 微生物学报
%D 2008
%I 
%X Bacterial spores are robust and dormant life forms with formidable resistance properties. Spores of the genus Bacillus have been used for a long time as probiotics for oral bacteriotherapy both in humans and animals. Recently, genetically modified B. subtilis spores and B. anthracis spores have been used as indestructible delivery vehicles for vaccine antigens. They were used as vaccine vehicles or spore vaccine for oral immunization against tetanus and anthrax, and the results were very exciting. Unlike many second generation vaccine systems currently under development, bacterial spores offer heat stability and the flexibility for genetic manipulation. At the same time, they can elicit mucosal immune response by oral and nasal administration. This review focuses on the use of recombinant spores as vaccine delivery vehicles.
%K bacterial spore
%K vaccine
%K vaccine vehicle
%K immunization<br>细菌芽胞
%K 疫苗
%K 疫苗载体
%K 细菌芽胞
%K 疫苗载体
%K Review
%K vaccine
%K 相关
%K 遗传操作
%K 热稳定性
%K 研究
%K 炭疽
%K 破伤风
%K 疗法
%K 食品生产
%K 人和动物
%K 应用
%K 益生菌
%K 菌属
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=4EBCECA81D99BC516A23D52B66CE91D8&yid=67289AFF6305E306&vid=B6DA1AC076E37400&iid=38B194292C032A66&sid=09AA1448D1EAF9C1&eid=84A93BA251D28205&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=23