%0 Journal Article
%T Marine microbial metagenomics:progress and prospect
海洋微生物宏基因组工程进展与展望
%A LI Xiang
%A QIN Ling
%A DAI Shi-kun
%A JIANG Shu-mei
%A LIU Zhi-heng
%A
李翔
%A 秦岭
%A 戴世鲲
%A 姜淑梅
%A 刘志恒
%J 微生物学报
%D 2007
%I
%X Preliminary statistics showed that there are more than one million species of microbes in marine environments that formed a dynamic genetic reservoir, among which the majority are not revealed and categorized due to barrier in cultivation techniques.However,the situation has changed in recent years because of the rapid development of phylogenetic studies based on small ribosomal RNA and rDNA sequencing independent to standard laboratory cultivation.These changes have significantly altered our understanding about microbial diversity and microbial ecology.In this review,we highlight some of recent progress and innovation in research on microbial diversity,and propose a metagenomic scheme as an alternative to overcome some of the barriers that still remain for exploitation of marine microbial diversity for its enormous potential in pharmaceutical applications.We believe that rapid progress in marine metagenomics allows direct access to the genomes of numerous non-cultivable microorganisms for their associated chemical prosperity.
%K metagenomics
%K microbial diversity
%K marine drug discovery
%K bacterial artificial chromosome
宏基因组学
%K 微生物多样性
%K 海洋药物发现
%K 细菌人工染色体
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=20F958E17B2FF282&yid=A732AF04DDA03BB3&vid=F4B561950EE1D31A&iid=38B194292C032A66&sid=E5D85F291CED2DA6&eid=4AB4178709047BE3&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=22