%0 Journal Article
%T Preparation and Osteoinduction Capacity of Collagen/Bone Morphogenetic Protein Composites<br>胶原蛋白/BMP复合材料的制备和成骨性能研究
%A Weiqiang Tan
%A Jinghong Xu
%A Youshan Liu
%A Jun Lin
%A Huiming Wang
%A <br>谈伟强
%A 徐靖宏
%A 刘友山
%A 林 军
%A 王慧明
%J 微生物学报
%D 2008
%I 
%X Collagen/bone morphogenetic protein composites were prepared with collagen type I sponge and bone morphogenetic protein-2 (BMP-2). The composites were implanted into Latissimus dorsi muscles pouches of rabbits. Samples were studied with ALP staining, Von Kossa staining, HE staining, toluidine blue staining and CD31 histochemical labeling of microvessel. Bony samples were then used to repair mandibular defect. The effects were evaluated by X-ray, compressive strength, economycin fluorescence labeling, HE staining, toluidine blue staining and bone quantity analysis. Bone formation induced by collagen/BMP composites was found as woven bone between 4 and 6 weeks; cartilaginous osteogenesis was the main type of bone formation; microvessels could be seen in the bony tissues; and the bone defects were healed completely 6 weeks after operation. Bone formation induced by collagen/BMP composites in the muscles can be used as a donor to repair the bone defect.
%K collagen
%K bone morphogenetic protein-2
%K BMP-2
%K bone defect
%K ectopic bone formation<br>胶原蛋白
%K 骨形态发生蛋白-2
%K 异位成骨
%K 骨缺损
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=97B54AE730DE07FE2F1DD37B09F4D7CD&yid=67289AFF6305E306&vid=B91E8C6D6FE990DB&iid=0B39A22176CE99FB&sid=4E6F5C60B72D9B1C&eid=CAA7BAE04CB631A1&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=0