%0 Journal Article
%T Influenceof lysozyme-like protein on virulence and capsular polysaccharide synthesis of Streptococcus pneumoniae<br>一种溶菌酶样蛋白对肺炎链球菌毒力及荚膜多糖合成的影响
%A Jian Huang
%A Xuemei Jiang
%A Meirong Huang
%A Xiaoliang Yang
%A Mingwei Liu
%A Hong Wang
%A Jianping Meng
%A <br>黄健
%A 姜学美
%A 黄美容
%A 杨晓亮
%A 刘明伟
%A 王虹
%A 孟江萍
%J 微生物学报
%D 2011
%I 
%X Objective]To study the biological character and pathogenic effect of a lysozyme-like protein in Streptococcus pneumoniae.Methods]The gene knockout mutant was constructed by the long flanking homology polymerase chain reaction.The mutant containing rescue plasmid to complement the lysozyme-like gene was also constructed.The differences in biology and pathogenicity in D39 wild strain,gene knockout mutant and gene knockout mutant containing rescue plasmid were observed to identify the functions of the lysozy...
%K Streptococcus pneumoniae
%K lysozyme
%K virulence
%K reverse mutation
%K capsule<br>关键词：肺炎链球菌
%K 溶菌酶
%K 毒力
%K 回复突变
%K 荚膜
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=7F88C3EABFEF9D08548A649280039F2C&yid=9377ED8094509821&vid=987EDA49D8A7A635&iid=CA4FD0336C81A37A&sid=6AC2A205FBB0EF23&eid=8BD23BD67BF01A5C&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=20