%0 Journal Article
%T Numerical Simulation of Chondrocyte Growth in 3-D Scaffolds<br>三维支架材料中软骨细胞生长过程的数值模拟
%A JIANG Hu
%A ZHOU Yan
%A TAN Wen-Song
%A <br>江华
%A 周燕
%A 谭文松
%J 微生物学报
%D 2007
%I 
%X Tissue engineering is a promising technique to repair or reconstruct the damaged cartilage in clinical use. However, chondrocyte growth is limited by the mass transport in scaffolds as diffusion is likely to be the primary mechanism. In this study, a mathematical model was developed based on oxygen diffusion and reaction to simulate chondrocyte growth. In order to accord with the fact, effective diffusion coefficients and space limitation were considered in this model and good agreement was found between experimental data and mathematical simulations. Furthermore, relationships established in the model system can be used to optimize the situation in real bioreactors and the design of three-dimensional scaffolds.
%K 组织工程，
%K 软骨细胞，
%K 多孔介质，
%K 数值模拟
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=C5FE564734E803A86C20B5B1A0A7683C&yid=A732AF04DDA03BB3&vid=EA389574707BDED3&iid=CA4FD0336C81A37A&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=0