%0 Journal Article
%T Screening and characterization of marine bacteria with antibacterial and cytotoxic activities,and existence of PKS Ⅰ and NRPS genes in bioactive strains<br>抗菌和细胞毒活性海洋细菌的筛选及其次生代谢基因证据
%A ZHU Peng
%A ZHENG Li
%A LI Jing
%A SHAO Jian-zhong
%A YAN Xiao-jun
%A <br>朱鹏
%A 郑立
%A 林晶
%A 邵健忠
%A 严小军
%J 微生物学报
%D 2007
%I 
%X Antibacterial and cytotoxic activities were screened for marine bacteria which have been isolated from organism, sediments and seawater in China coastal area. The results showed that 42 isolates had antimicrobial activity and 12 isolates had cytotoxicity. Molecular phylogenetic analysis of marine bacteria with cytotoxicity based on 16S rRNA sequences indicated that they were belong to the genera Aerococcus, Agrobacterium, Alteromona, Bacillus, Exiguobacterium, Paracoccus, Pseudoalteromons, Rheinheimera. Furthermore, marine bacteria with cytotoxicity were also screened for PKS I and NRPS genes which could be responsible for bioactive secondary metabolites biosynthesis, 4 strains having KS domain or A domain were obtained, which provide strong evidence that marine bioactive bacteria can produce natural products through PKS and NRPS pathways.
%K 16S rRNA<br>海洋细菌
%K 抗菌
%K 细胞毒
%K 多聚酮合酶(PKS)
%K 非核糖体肽合成酶(NRPS)
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=34FCAB29F7E54023&yid=A732AF04DDA03BB3&vid=F4B561950EE1D31A&iid=0B39A22176CE99FB&sid=CA5852BD1A173B3A&eid=D9AE183D3F5C3C75&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=27