%0 Journal Article
%T Advances in the study of the mechanism and application of nonribosomal peptide synthetases<br>非核糖体肽合成酶(NRPSs)作用机理与应用的研究进展
%A WANG Shi-yuan
%A <br>王世媛
%J 微生物学报
%D 2007
%I 
%X Many microorganisms could use nonribosomal peptide synthetases (NRPSs) to synthesize various bioactive peptides with complicated structures. Because of their special physical-chemical and pharmacological properties, the nonribosomal peptides (NRPs) had been extensively studied, and would have great potential for commercial application. NRPSs are composed of many iterative modules whose different assembling orders determine the specificity of amino acid sequences of their peptide products. The NRPs are assembled by NRPSs via multiple-carrier thiotemplate mechanism, and the substrate specificity of NRPSs is determined by both adenylation domain and condensation domain. Recently, many expected peptides were synthesized using natural whole NRPSs, some specific domains of NRPSs, or novel NRPSs which were constructed by the combination or hybrid combination of specific modules or domains of some known NRPSs.
%K nonribosomal peptides (NRPs)
%K nonribosomal peptide synthetases (NRPSs)
%K module
%K mechanism
%K application<br>非核糖体肽
%K 非核糖体肽合成酶
%K 模块
%K 作用机理
%K 应用
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=BB91B001C728166E&yid=A732AF04DDA03BB3&vid=F4B561950EE1D31A&iid=E158A972A605785F&sid=7F9B7E84827A650F&eid=8CC50269EED5BB47&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=27