%0 Journal Article
%T In vitro inhibitory efects on HBsAg and HBeAg secretion of 3 new components produced by Ganoderma lucidum in the medium contained Radix sophorae flavescentis extract<br>灵芝转化苦参水提物的3个新生成分体外抗乙型肝炎病毒作用
%A LI Yan-qun
%A ZHANG Ke-chang
%A <br>李雁群
%A 章克昌
%J 微生物学报
%D 2005
%I 
%X In order to enhance the medical effects of Ganoderma lucidum submergedly cultured broth, the aqueous extract of Radix sophorae flavescentis, a traditional Chinese medicine, was added into the cultivation medium of G. lucidum. The organic acids were extracted with ethanol, chloroform, 5% NaHCO-3 and chloroform in turn from the cultured broth of Ganoderma lucidum which cultivation medium contained Radix sophorae flavescentis extract. Six new components were separated from the organic acids with preparative HPLC. Their inhibitory effects on HBsAg and HBeAg secretion of HBV DNA transferred HepG2 cell (2.2.15 cell) were investigated. The results indicate that 3 components of the six have significant inhibitory effects on the antigen secretion.
%K Ganoderma lucidum
%K Radix sophorae flavescentis
%K Hepatitis B Virus
%K Submerged culture
%K Anti-virus<br>灵芝
%K 苦参
%K 乙肝
%K 液体培养
%K 抗病毒
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=BAE033BB7E0E64F6&yid=2DD7160C83D0ACED&vid=94E7F66E6C42FA23&iid=E158A972A605785F&sid=5DD21DF25EF52D4A&eid=6C62BFE34266FA92&journal_id=0001-6209&journal_name=微生物学报&referenced_num=2&reference_num=11