%0 Journal Article
%T Advances in the study of nisin Resistance-A review<br>乳链菌肽（nisin）抗性机制的研究进展
%A Xiaodong Chu
%A Yuheng Lin
%A Zhizeng Sun
%A Liandong Huan
%A Jin Zhong
%A <br>初晓东
%A 林宇恒
%A 孙志增
%A 还连栋
%A 钟瑾
%J 微生物学报
%D 2010
%I 
%X Abstract: Nisin, a lantibiotic produced by some species of Lactococcus lactis, has broad antibacterial spectrum against Gram-positive bacteria species, especially those with close phylogenetic relationship to the nisin producing strain. The broad use of nisin did not lead to widespread resistence. However, some non-nisin producing bacteria could develope certain mechanisms of resistance against nisin when growing under laboratory or nature selection pressure. Nisin resistance mainly involved two strategies, namely, the non-specific physiological isolation mechanism (by the change of cell wall or membrane structure and composition) and the specific protease-mediated mechanism. This review introduced the advances in the study of nisin resistance mechanism.
%K Keywords: nisin
%K resistance
%K nisin resistance protein (NSR)<br>关键词：乳链菌肽
%K 抗性
%K nisin抗性蛋白（NSR）
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=9EC53CF940ABD2874F9B9E85EDC84516&yid=140ECF96957D60B2&vid=771152D1ADC1C0EB&iid=9CF7A0430CBB2DFD&sid=2C195A225F9C61A0&eid=9F83C44826B8A7D6&journal_id=0001-6209&journal_name=微生物学报&referenced_num=1&reference_num=0