%0 Journal Article
%T Random Forest for Classification of Thermophilic and Psychrophilic Proteins Based on Amino Acid Composition Distribution<br>基于氨基酸组成分布的嗜热和嗜冷蛋白随机森林分类模型
%A Guangya Zhang
%A Baishan Fang
%A <br>张光亚
%A 方柏山
%J 微生物学报
%D 2008
%I 
%X We used amino acid composition distribution (AACD) to discriminate thermophilic and psychrophilic proteins. We used 10-fold cross-validation and independent testing with other dataset to evaluate the models. The results showed that when the segment was 1, the overall accuracy reached 92.9% and 90.2%, respectively. The AACD method improved the prediction accuracy when support vector machine was used as the classifier. When six new features were introduced, the overall accuracy of random forest improved to 93.2% and 92.2%, the areas under the receiver operation characteristic curve were 0.9771 and 0.9696, which was better than other ensemble classifiers and comparable with that of SVM.
%K Random forest
%K amino acid composition distribution
%K thermophilic and psychrophilic protein
%K ROC curve<br>随机森林
%K 氨基酸组成分布
%K 嗜热和嗜冷蛋白
%K ROC曲线
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=61C07046374178CA34D1F8B21DF1FECB&yid=67289AFF6305E306&vid=B91E8C6D6FE990DB&iid=0B39A22176CE99FB&sid=119B6C0AA09DE6B9&eid=51C74DF6A16DA45B&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=0