%0 Journal Article
%T Screening and breeding of high lysine-producing strains by genome shuffling<br>用基因组重排技术选育赖氨酸高产菌株
%A Kai Zhao
%A Wei Duan
%A Lixin Sun
%A Dongpo Zhou
%A <br>赵凯
%A 段巍
%A 孙立新
%A 周东坡
%J 微生物学报
%D 2009
%I 
%X Abstract: Objective] To screen and breed high lysine-producing strains by genome shuffling. Methods] Corynebacterium pekinense 1 was used as the starting strain in this study. High lysine-producing strains were screened by genome shuffling. Results] Five hereditarily stable strains with high lysine production were obtained by four cycles of genome shuffling. A high lysine producing strain, F4-36, was obtained, which produced 16.95 g/dL lysine, 37.1% higher than that of the starting strain. Conclusion] Genome shuffling can be an efficient tool to screen and breed high lysine production strains.
%K Keywords: lysine
%K lysine-producing strain
%K genome shuffling<br>关键词：赖氨酸
%K 赖氨酸产生菌
%K 基因组重排
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=2DA14762F40F0D116C9A28B12C453055&yid=DE12191FBD62783C&vid=2A3781E88AB1776F&iid=5D311CA918CA9A03&sid=6A12B9FCEF71AE29&eid=4AB97D697AC3192E&journal_id=0001-6209&journal_name=微生物学报&referenced_num=3&reference_num=18