%0 Journal Article
%T YPK1 overexpression resulted salt stress hypersensitivity in Saccharomyces cerevisiae is dependent on TOR1<br>过量表达蛋白激酶YPK1使酵母细胞对高盐胁迫的高度敏感依赖于雷帕霉素靶蛋白
%A Hongping Cao
%A Yihui Wang
%A Yan Zhong
%A Xin Liu
%A Ming Miao
%A Wei Duan
%A Ke Liu
%A <br>曹红平
%A 王一慧
%A 钟彦
%A 刘昕
%A 苗敏
%A Wei Duan
%A 刘科
%J 微生物学报
%D 2009
%I 
%X Abstract: Serine/threonine protein kinase YPK1, a homologue of mammalian protein kinase serum and glucocorticoid-inducible kinase (SGK), plays important physiological roles in Saccharomyces cerevisiae. It involves in cell wall maintenance, actin cytoskeleton dynamics, endocytosis, translation during nitrogen starvation and nutrient sensing. Objective] In order to further explore the cellular function of YPK1 and the its transduction pathway. Methods] We overexpressed YPK1 in wild type and tor1 mutant cells and monitored the cell growth responding to salt stress. Results] We found that YPK1 overexpression resulted salt stress hypersensitivity in wild type cells and this hypersensitivity was abolished by tor1 mutant. Conclusion] Our results indicate that YPK1 may interact with target of rapamycin (TOR1) to regulate the salt stress response.
%K Keywords: Saccharomyces cerevisiae
%K YPK1
%K TOR1
%K protein kinase
%K salt stress<br>关键词：酵母
%K YPK1
%K 雷帕霉素靶蛋白（target
%K of
%K rapamycin
%K TOR1）
%K 蛋白激酶
%K 盐胁迫
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=89C3D041D7CDFAFA31E65A2EF1678F1E&yid=DE12191FBD62783C&vid=2A3781E88AB1776F&iid=5D311CA918CA9A03&sid=81A5772701933E75&eid=CD794621A184DC14&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=17