%0 Journal Article
%T Antigen signature analysis of dengue-2 viruses strains in Hainan China<br>用标记分析法对我国海南地区登革2型病毒株的抗原表位分析
%A P Y Yang
%A B Y Si
%A G Z Yan
%A P F Xu
%A R X Li
%A <br>杨佩英
%A 司炳银
%A 阎国珍
%A 徐品芳
%A 李瑞霞
%J 微生物学报
%D 1989
%I 
%X In this paper, we try to define the extent of antigenic variation between dengue-2 viruses from Hainan province, which had been isolated over a period of 3 years (1985-1987). The dengue-2 viruses were compared with the prototype New Guinea B strain and were subjected to antigen signature analysis. Eight strains of dengue-2 virus were analyzed by three monoclonal antibodies: flavivirus group, subcomplex dengue-2 type-specific reactive epitopes, over a range of antigen concentration. Five out of eight dengue-2 virus strains showed them to be antigenically homogeneous, and the remaining three strains showed them to be heterogeneous. Signature analysis provides a rapid and simple means to different strains derived from different sources, thus permit monitoring changes or introductions of hew dengue virus populations in certain geographic region.
%K 登革2型病毒
%K 标记分析
%K 单克隆抗体
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=9D4495AC2B00B56EC0B3286D1FE77C8A&yid=1833A6AA51F779C1&vid=771469D9D58C34FF&iid=E158A972A605785F&sid=BF112261B65CB9C9&eid=119B6C0AA09DE6B9&journal_id=0001-6209&journal_name=微生物学报&referenced_num=1&reference_num=2