%0 Journal Article
%T The Optimization of Guanosine Fermentation Based on Process Parameter Correlation Analysis<br>基于过程参数相关分析的鸟苷发酵过程优化
%A Cai Xianpeng Chen Shuangxi Chu Ju Zhuang Yingping Zhang Siliang
%A <br>蔡显鹏
%A 陈双喜
%A 储炬
%A 庄英萍
%A 张嗣良
%A 王焕章
%A 刘咏梅
%J 微生物学报
%D 2002
%I 
%X The characteristic of Bacillus.subtilis fermentation process of guanosine on 50L fermentor was analyzed. Based on determination of on-line and off-line parameter, using correlation analysis, the technology study of physiologic regulation was combined with the metabolic flux distribution of synthesis process. The metabolic flux shift from HMP to EMP and TCA cycle during fermentation was found. The reason of the flux shift was preliminary analyzed, based on which the procedure was optimized to increase the yield of guanosine to 30g/L.
%K Guanosine
%K Correlation analysis
%K Metabolic flux shift<br>鸟苷，
%K 相关分析，
%K 代谢流迁移
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=61B49A0081760AF2&yid=C3ACC247184A22C1&vid=ECE8E54D6034F642&iid=0B39A22176CE99FB&sid=E1D946F217E3B046&eid=6CCE24D86D03D083&journal_id=0001-6209&journal_name=微生物学报&referenced_num=9&reference_num=10