%0 Journal Article
%T Biosynthetic Regulation of Secondary Metabolites in Streptomycetes by Two-component Regulatory Systems<br>链霉菌次生代谢中双因子调控系统的研究进展
%A GONG Cai-Xia
%A LI Ai-Ying
%A <br>宫彩霞
%A 李爱英
%J 微生物学通报
%D 2010
%I 
%X A vast number of secondary metabolites are produced in Streptomycetes under the tight control by many regulators, including two-component regulatory systems. Two-component regulatory systems with high diversity are widely distributed in Streptomycetes and perform positive or negative regulation by different and complex modes during secondary metabolites biosynthesis. Here, we reviewed some research advances on these systems involved in secondary metabolites accumulation in streptomycetes, mainly focusing on the clarification of their action modes. We also prospected the research trends in this field and application of two-component regulatory systems in the metabolic engineering of natural products.
%K Streptomycetes
%K Secondary metabolite
%K Biosynthetic regulation
%K Two-component regulatory system<br>链霉菌
%K 次生代谢
%K 合成调控
%K 双因子调控系统
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=78024727B5F4EF6AA9CA8E605B5FC464&aid=E0D7881F2986278051EC88883F58841C&yid=140ECF96957D60B2&vid=42425781F0B1C26E&iid=B31275AF3241DB2D&sid=8B407001D97E3B1A&eid=6575F6659CF52298&journal_id=0253-2654&journal_name=微生物学通报&referenced_num=1&reference_num=0