%0 Journal Article
%T Advances in the Research on the Brucella Intracellular Life<br>布鲁氏菌胞内生存机制研究进展
%A WANG Yu-Fei
%A CHEN Ze-Liang
%A HUANG Liu-Yu
%A <br>王玉飞
%A 陈泽良
%A 黄留玉
%J 微生物学通报
%D 2007
%I 
%X Brucella organisms are facultative intracellular bacteria capable of surviving inside professional and non-professional phagocytes.Upon cell contact the bacteria is internalized via receptor molecules.Once inside cells,Brucella localizes in early phagosomes,where it avoids fusion with late endosomes and lysosomes.Then,the bacterium redirects its trafficking to autophagosomes and finally reaches the endoplasmic reticulum,the replicating niche.Once inside the endoplasmic reticulum,Brucella extensively replicates without restricting basic cellular functions or inducing damage to cells.Invasion,intracellular trafficking and replication of Brucella organisms in professional and non-professional phagocytes and the molecular determinants involving Brucella intracellular life are reviewed in this article.
%K Brucella
%K Bacterial invasion
%K Intracellular trafficking
%K Intracellular replication<br>布鲁氏菌
%K 细菌侵袭
%K 胞内运输
%K 胞内复制
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=78024727B5F4EF6AA9CA8E605B5FC464&aid=E0212BB6D3C185EA8A4662A1BC6D6188&yid=A732AF04DDA03BB3&vid=339D79302DF62549&iid=B31275AF3241DB2D&sid=E2F55FDAFC844F27&eid=EC37857E7CB2811A&journal_id=0253-2654&journal_name=微生物学通报&referenced_num=0&reference_num=35