%0 Journal Article
%T Breeding of a High Mizoribine-producing Strain by Composite Mutation with UV and NTG<br>UV与NTG复合诱变选育咪唑立宾高产菌
%A ZHANG Zhu-Lan
%A TANG Wen-Li
%A YANG Huang-Jian
%A REN Lin-Ying
%A SUN Fei
%A ZHENG Rong
%A <br>张祝兰
%A 唐文力
%A 杨煌建
%A 任林英
%A 孙菲
%A 郑榕
%J 微生物学通报
%D 2010
%I 
%X Eupenicillum sp. E-0509-2 was used as an original strain to carry out mutagenetic breeding adopting UV, NTG and UV + NTG, respectively. The spore suspension of E-0509-2 was treated by UV irradiation for 60 seconds, followed with 3.0 g/L NTG for 20 minuites under magnetic stirring. After further screening experiments on fermentation, a mutant Eupenicillum sp. E-UN41 which was able to produce mizoribine with high yield and could be stably passed on genetics was eventually found. The Mizoribine yield of Eupenicillum sp. E-UN41 was enhanced more than 13 times higher than that of the original strain.
%K Mizoribine
%K Eupenicillum
%K Composite mutation<br>咪唑立宾
%K 正青霉菌
%K 复合诱变
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=78024727B5F4EF6AA9CA8E605B5FC464&aid=8B8C8B19364B7E8C5730A836360CB51A&yid=140ECF96957D60B2&vid=42425781F0B1C26E&iid=B31275AF3241DB2D&sid=D0AD7028B3BB6376&eid=9A66B59A1D0489DC&journal_id=0253-2654&journal_name=微生物学通报&referenced_num=0&reference_num=0