%0 Journal Article
%T STUDY ON OPTIMIZATION OF GUANOSINE FERMENTATION<br>鸟苷发酵的优化研究
%A CHEN Shuang-Xi
%A CAI Xian-Peng
%A WANG Zhong-Shi CHU Ju
%A ZHUANG Ying-Ping
%A ZHANG Si-Liang
%A <br>陈双喜
%A 蔡显鹏
%A 王仲石
%A 储炬
%A 庄英萍
%A 张嗣良
%J 微生物学通报
%D 2002
%I 
%X Bacillus subtilis AJ2066 was used to yield guanosine. The optimization of guanosine fermentation was studied by means of flask coupled with 50L auto-controlled fermentor. Monosodium glutamate is important to guanosine fermentation. The yield reached 31.49g/L in 50L fermentor with the medium supplemented with 1% monosodium glutamate. Hypoxanthine (Hx) can be used to synthesize guanosine directly as precursor. The yield reached 33.24g/L in 50L fermentor by supplementing 0.2% hypoxanthine during final stage of fermentation.
%K Guanosine
%K Fermentation
%K Coupled-optimization<br>鸟苷
%K 发酵
%K 联动优化
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=78024727B5F4EF6AA9CA8E605B5FC464&aid=377AFF9153A7A495&yid=C3ACC247184A22C1&vid=771469D9D58C34FF&iid=94C357A881DFC066&sid=8BD23BD67BF01A5C&eid=CB423C9A71560A74&journal_id=0253-2654&journal_name=微生物学通报&referenced_num=3&reference_num=9